The worlds most powerful pistol is the Austrian Pfeifer-Zeliska .600 Nitro Express Magnum. It is chambered to fire the British developed .600 caliber rifle bullet originally made by Holland and Holland. This revolver was not originally a full production model but a one off, built especially for a wealthy Swiss gent...Mr. Zeliska.
But if you would like one and I am sure that a few of you 'gunslingers' with a bit of disposable income would, then contact Pfeifer arms, and they will make one for you. Priced at 13,840 Euro's. This equates as $17,316* or £11,722* including Tax ( *at Exchange rate as of 20 November 2008 )
Url: http://www.vincelewis.net/60magnum.html
So, if you want to shoot one, better lift a few weights first....
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A VERY good handgun- for most puposes. Durable, reliable, accurate, and powerful.
Probably, almost certainly, the .600 Nitro Express is the overall most power handgun bullet. Let me alter this answer by saying the .600 Nitro Express is a rifle round that one company made a pistol for. The most powerful handgun cartridge is the 500 S&W Magnum.
Eminent Tech TRW 17 is the worlds most powerful subwoofer.
Not even close. There are several more powerful handgun cartridges, not counting the single shot pistols that use rifle cartridges. While Dirty Harry may have proclaimed it to be "The most powerful handgun in the world"- it is not.
United States Military
the most powerfull locomotive is soviet 2TE126
There are many handgun rounds that exceed the 44 mag. 454, 460, 500 to name a few.
Fairly certain it is the Thompson Contender .600 Nitro Express for production firearms.
Can't be answered withou knowing if you are referring to a rimfire or centerfire 22