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There may be a difference in taste, and the generic will almost certainly cost less than the name brand, but many of the same companies that make name brand products also make the generic ones.
Nothing really actually. Different brands use different sweeteners, but as a general rule they all have sugar or if it be diet, Aspartame or Splenda. Aspartame can make the drink taste very synthetic in my opinion. Anyways, the only noticeable difference comes from cola products in which there are varying levels of actual Cola Syrup. Coke uses a lot more than most brands which is why people tend to describe it as having a "weird feeling" on their teeth.