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No. The number 1 cause is Heart disease. However, that is an effect of smoking, furthermore, smoking also causes the 2nd, 3rd, and 4th leading causes of death, which are cancer, stroke, and chronic lower respiratory disease, respectively.

Smoking can not be called a cause of death by itself; it simply causes diseases that account for more deaths that anything else.

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Q: Is smoking the number one killer in US?
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