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Generally speaking no, but there are many conflicting studies on the subject. Some say that there are no negative long term effects and others say there are numerous. The consensus at this point seems to have become more in favor of marijuana than anything. Most studies do show the drug in a positive light. There is even some evidence that marijuana has some amazing medicinal purposes, such as killing brain cancer cells, which are being investigated. The plant has also been used quite successfully in treating pain and nausea for various patients, namely chemotherapy patients. Furthermore, it is used in treating glaucoma patients because it reduces pressure in the eyes and aids in the healing process.

It is also impossible to overdose on marijuana and there has never been a single death directly related to the consumption or inhalation of the drug.

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