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You'll get resin on it and it'll smell like weed. It may also become dry. There is a very small chance that it will cause plastisol migration, a chemical reaction that causes plastics to slowly break down. But i honestly don't think it'll affect your retainer much, lil smokey. If you're that concerned, take it out while you smoke. But keep in mind that many "water pipes" have a plastic recipticle and the smoke does not seem to damage them. so i think you're safe.
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