Well that depends on a lot of things, like how much weight you put on, where the weight is, and what you are willing to do to work it off.
Are you off of the anti-depressant due to excessive weight gain? Taking the supplement 5-HTP helps to naturally increase the body's level of serotonin (if your medication had anything to do with serotonin) and helps to control the appetite. Dieting and excercise will help to jump start your weight loss, start eating right and do some aerobics!
It's hard to just hear "anti-depressant" with no amount of weight gain and be able to answer your question.
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