There is no specific reference to her red eyes in the original story. However, it has been symbolic of Mrs Cratchit sewing with her daughters when she declares her eyes are weak from sewing by candle light, the colours hurt her eyes . This infact covers her tears shed for the passing of Tiny Tim
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Mrs. Cratchit's eyes are likely red from crying and emotional distress, as her family is struggling financially and her young son, Tiny Tim, is ill. The stress of their situation and the uncertainty of their future may also contribute to her tired and sorrowful appearance.