One difference between a desktop and a laptop is that a laptop is portable while a desktop is stationary. Laptops are usually smaller and can run off of battery power while a desktop is bigger and has to be plugged in to work.
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For starters, the "difference" should be obvious in the names. Laptop means well...a computer you sit in your lap. Desktop means a computer that rests on your desk. A laptop is a portable computer. they are small and compact...for more info...please Google laptops. A desktop is NOT portable....Google Desktops.