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In digital subtraction angiography (DSA), an image is obtained prior to the introduction of the radio-opaque contrast medium. This image is then digitally "subtracted" by turning it into a "negative" and then superimposing the image onto images acquired after the injection of contrast. This theoretically results in everything but the image of contrast within the vessel being subtracted, or removed, leaving a clearer picture. Often due to patient movement, breathing etc, the two images do not exactly superimpose and some residual shadow of the surrounding structures may be visible.

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Q: Difference between angiography and Digital subtraction angiography?
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