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Prosthetic groups can be as simple as a single metal ion bound into the enzyme's structure, or may be a more complicated organic molecule (which might also contain a metal ion). it is permanently bonded to enzyme.

Activator is only metal ion that is detachable.

source:chemguide.co.uk

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An activator is a molecule that binds to an enzyme and enhances its catalytic activity, while a prosthetic group is a non-protein molecule that is permanently attached to an enzyme and is required for its activity. Prosthetic groups usually participate in the catalytic reaction, while activators simply increase the enzyme's efficiency.

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Q: Difference between activator and prosthetic groups?
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What is the difference between coenzyme and prosthetic group?

A coenzyme is a non-protein compound that binds to an enzyme to help it function properly, while a prosthetic group is a non-protein component that is permanently attached to an enzyme and is essential for its activity. In other words, coenzymes are temporary helpers, while prosthetic groups are permanent additions to the enzyme structure.


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Prosthetic group of enzyme is organic or inorganic?

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