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Both MDs and DOs tend to begin training by getting a four-year undergraduate degree, either in pre-med, or in a related science field. Each type of doctor will then complete four years of training before taking examinations that will result in licensure. Either type of doctor may then choose to specialize in a particular field and study for two to six more years. The Doctor Who specializes will then take further examinations to be licensed by the board of his or her specialty.

In most cases, the four years of medical school are quite similar. However the DO receives training in the muscular and skeletal system, and also in muscular and skeletal manipulation. A doctor who is a DO tends to evaluate a person's health in terms of viewing the body as a complex related network. Any disease affects the whole body. The MD, conversely, may evaluate the disease in terms of how it affects certain parts of the body only.

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