Can you use a 22 cal round in a 25 cal gun?

Answer 1

Usually, no. In the case of the .22 long rifle cartridge loaded into a small .25 pistol, because the .22 cartridge is smaller, it is not held firmly in the .25 caliber chamber in a position that lets the firing pin hit the primer on the cartridge. In the rare event that you did get the cartridge to fire, the bullet would pass down the barrel but because it is too small to engage the barrel rifling, the accuracy would be very poor. On the other hand, it would be pretty easy to load a .22 bullet in a necked down brass casing of a larger rifle cartridge, such as a centerfire .25 caliber rifle. But, even though now ignition would be very certain because the base of the cartridge now aligns perfectly with the firing pin, accuracy would still be poor because the bullet would still not be big enough to engage the rifling. Picture in your mind, a Baseball bouncing through the inside of a large pipe. It will come out the other end, but you have no idea where it will go after that.