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The short answer to your question is... yes, of course you CAN. I think what you intended to ask is if it is safe to do so. Cigarette smoking is never really a good idea- it is a major contributor to unpleasant events like cancer, strokes, and the occasional heart attack. Having given that disclaimer, however, there is no specific reason why there is any additional concern for your health if you smoke while taking Seroquel.
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