Can you shoot 22 shorts in a ruger Mark 1 22?

Answer 1

NEVER SHOOT AMMUNITION IN A WEAPON THAT IS NOT DESIGNED FOR IT!!!!!!!!!!!!!!

Danger, danger, danger.

EDITED TO GIVE A MORE REASONABLE AND USEFUL ANSWER: If you single-load the .22 shorts into the chamber of this .22LR pistol, this is safe. They will fire and should give satisfactory performance at close range. If you shoot a lot of .22 shorts in a gun chambered for .22 LR, make sure to clean the chamber well using a bore brush to remove the ring of fouling that will build up. Do not expect the little .22 shorts to feed through the magazine of this gun or any other repeating firearm (pump action, lever action, magazine-fed bolt action) that was made to use the longer .22 LR rounds. SUGGESTION: If you want reduced power and reduced-noise ammo for this pistol, try CCI's "CB Long" cartridges. They are quieter than .22 shorts and they use a standard-length "long rifle" brass case. They probably won't feed through the magazine (the overall round is still shorter because of the small bullet compared to a long rifle round) but they won't deposit any fouling in your chamber or cause any issues when switching back to standard .22LR ammo later.