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1. Not advised.
2. The .22 LR round will burst and unravel in a .22 magnum chamber nearly every time. It will fire a bullet downrange though and accuracy will be poor.
The gasses will exit the burst cartridge, usually harmlessly, though, and it it not advised as above.
However there are sleeves that can safely convert a .22 magnum chamber to use a .22 Long Rifle cartridge with no problems. The sleeve fits around the .22 LR cartridge.
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