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i wouldn't suggest it, at least not a lot of alcohol. Desmopressin basically works by decreasing the amount of urine your body produces, so drinking a large sum of alcohol or any other fluid for that matter will most likely make you feel bloated and uncomfortable because the fluids that would normally be removed via urination will stay in your body much longer. This could also disrupt your levels of sodium and other nurtients in your blood. Also, it will give you a hangover.

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Q: Can you drink alcohol on desmopressin?
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