It depends on what you want to compare. The pistols themselves may or may not be different, it just depends on which two specific brands/models you are comparing. If you are referring to the 10mm cartridge vs. the .40SW, the .40 is shorter and has much less muzzle velocity and energy than a 10mm. The piece of lead however, is the same, normally ranging from 135 grains to 180 grains, although some are 200 grains.
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