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Yes. After getting a positive test result when I was pregnant with my son, I took another test to show my husband's parents. I accidentally peed on the result window and the test came out negative. I don't know if it's always invalid, but it happened with me, so there you go :)
I've learned to just pee in a cup and dip the test in.
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Earn +20 ptsQ: Can results be invalid if you peed on result window of pregnancy test?
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