Methylprednisolone (MPSO) is a corticosteroid drug used to treat a wide variety of inflammatory conditions. It is a powerful drug with many possible side effects, some of them severe.
Although there is no clear contraindication for use of MPSO with alcohol, it should be done with caution, since both are powerful drugs. Alcohol can suppress liver function when used over long periods, and MPSO is metabolized by the liver. Under conditions of reduced liver functions, the MPSO level could rise above the optimum and cause problems including psychotic episodes.
Since alcohol can also cause psychotic episodes, the combination could be problematic. We would recommend approaching the combined use of the two drugs with great caution, under the guidance of your physician and pharmacist.
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