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A rifle with a 5.56x45 chamber can utilise .223 Remington cartridges. A rifle with a dedicated .223 Remington chamber cannot accommodate 5.56x45 cartridges. A rifle with a .223 Wylde chamber can accommodate .223 Wylde, .223 Remington, and 5.56x45, but neither a rifle with a 5.56x45 or a .223 Remington chamber can accommodate the .223 Wylde cartridge.

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Q: Are 223 and 5.56 interchangeable
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