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Why a mutation which changes at least one amino acid in a protein sequence results in a change in shape of the protein formed?
Wiki User
∙ 12y ago
each amino acid helps build the new strand of DNA. Messenger RNA splits and replicates a strand of DNA. Therefore, if there is a mutation in the amino acid, the DNA cannot be replicated exactly. This could change the function of the protein for good, for worse, or there could be no change at all.
This is a little backwards, but the essentials are there. There is not a mutation in the amino acid; they are what they are and don't change their chemical identity. The mutation can occur in the DNA molecule itself or in RNA, which either transcribes (mRNA) or translates(tRNA) the DNA code incorrectly. In either case, if the DNA is either coded incorrectly on the chromosome or if its code is read incorrectly by either RNA molecule, the code will end up scrambled and the wrong amino acid will be brought to the developing protein molecule and so the chemical nature of the protein is changed. Proteins are specific for function, so if even one amino acid in a chain of thousands is incorrect, then yes..the protein can change its function (which is usually harmful to the organism or cell) or be rendered useless, which is also bad.
For example, people with hemophelia lack a particular enzyme (protein molecules that catalyze cellular chemical processes) in the clotting mechanism, so the blood takes a very, very long time to clot, if at all. This is because there is a gene on the DNA which is missing, so that particular enzyme protein molecule is not synthesized properly and affects the function of the entire enzyme chain responsible for proper blood clotting.
Proteins are made of chains of amino acids strung together, so if even one of them is incorrect, the structure of the protein is changed, along with its chemical function in the cell.
Wiki User
∙ 12y ago
A mutation that changes an amino acid in a protein sequence can alter the interactions within the protein structure, affecting its folding pattern. This can disrupt the overall shape of the protein by changing the positions of key functional groups, ultimately impacting the protein's function.
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Most genetic disorders results from a mutation that changes the amino acid sequence in a?
Most genetic disorders result from a mutation that changes the amino acid sequence in a protein. This change can lead to altered protein function, which can affect normal cellular processes and result in disease.
A change in the sequence of DNA that results in a protein that is too short?
Nonsense mutation
Which genetic change is best described by the following statement A random change in the base sequence of DNA results in an alteration of a polypeptide?
A point mutation is best described by this statement. Point mutations occur when there is a change in a single nucleotide base in the DNA sequence, which can lead to changes in the corresponding amino acid sequence of a polypeptide during protein synthesis.
What is the most common type of mutation?
The most common type of mutation is a point mutation, where a single nucleotide base is changed, inserted, or deleted in the DNA sequence. This can result in a different amino acid being incorporated into the protein during translation, leading to potential changes in the protein's function.
How can a point mutation alter the final structure of a protein?
A point mutation can alter the final structure of a protein by changing a single nucleotide in the DNA sequence, leading to a different amino acid being incorporated into the protein sequence during translation. This change can disrupt the folding of the protein, affect its stability, alter its function, or impact its interaction with other molecules. Ultimately, these changes can result in a protein with different structural and functional properties than the original protein.
Most genetic disorders results from a mutation that changes the amino acid sequence in a?
Most genetic disorders result from a mutation that changes the amino acid sequence in a protein. This change can lead to altered protein function, which can affect normal cellular processes and result in disease.
A change in the sequence of DNA that results in a protein that is too short?
Nonsense mutation
Which genetic change is best described by the following statement A random change in the base sequence of DNA results in an alteration of a polypeptide?
A point mutation is best described by this statement. Point mutations occur when there is a change in a single nucleotide base in the DNA sequence, which can lead to changes in the corresponding amino acid sequence of a polypeptide during protein synthesis.
What is the most common type of mutation?
The most common type of mutation is a point mutation, where a single nucleotide base is changed, inserted, or deleted in the DNA sequence. This can result in a different amino acid being incorporated into the protein during translation, leading to potential changes in the protein's function.
What is the difference between a nonsense mutation and a missense mutation?
Missense mutation: changes one sense codon to another, resulting in incorporation of amino acid.Nonsense mutation: changes a sense codon into a stop (or nonsense) codon, resulting in premature termination.
When when a mutation results in no significant change in the production of a of a functional protein?
When a mutation does not change the result of a normal production of a protein is called harmless. This is because it does no harm to the individual.
Which type of mutation results in the formation of a protein with one incorrect amino acid-?
A point mutation, specifically a missense mutation, is responsible for the formation of a protein with one incorrect amino acid. This type of mutation involves a single nucleotide change in the DNA sequence, leading to the substitution of one amino acid in the protein.
What type of mutation could result in a much shorter protein than the original gene product?
A frameshift mutation, such as an insertion or deletion of nucleotides, can cause a shift in the reading frame of a gene during translation, leading to a premature stop codon. This results in a truncated protein that is much shorter than the original gene product.
What type of mutation results when nucleotide is dropped from a DNA sequence?
deletion
Which type of mutation results in abnormal acid sequence?
A point mutation causes a change in the amino acid sequence creating a new type of protein. The mutations are categorized functionally as nonsense, missense and silent mutations.
What results in a regular size protein that is misshapen?
Missense mutation
Describe the three types of Mutations?
The three major types of mutations generally are point mutation, insertion, and deletion. Point Mutation - This is when one base is substituted or changed into another base. Typically it changes from a purine to a purine, or pyrimidine to pyrimidine Insertion - A base is inserted into the DNA sequence shifting all of the other bases. Deletion - A base is deleted from the DNA sequence shifting all of the other bases.
