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This is a rather tricky question. Nascent proteins may be folded right upon the ribosome that makes them - in this case the answer would be the ribosome, or the cytoplasm.

However, most of the folding and post-translational modifications occur in the endoplasmic reticulum and the Golgi-apparatus.

To further complicate the issue, all biological function of proteins hinges on their 3D shapes, so the folding process never actually stops for good - processes such as phosphorylation for activation/inactivation also change the tertiarry/quarternarry structure, and can be considered micro-folding.

Rough endoplasmic reticulum.......

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9y ago

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