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This is a rather tricky question. Nascent proteins may be folded right upon the ribosome that makes them - in this case the answer would be the ribosome, or the cytoplasm.

However, most of the folding and post-translational modifications occur in the endoplasmic reticulum and the Golgi-apparatus.

To further complicate the issue, all biological function of proteins hinges on their 3D shapes, so the folding process never actually stops for good - processes such as phosphorylation for activation/inactivation also change the tertiarry/quarternarry structure, and can be considered micro-folding.

Rough endoplasmic reticulum.......

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9y ago

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The endoplasmic reticulum (ER) is the organelle responsible for folding proteins in the cell. Proteins are synthesized by ribosomes attached to the rough ER, and then they are properly folded and processed before being transported to their final destination.

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AnswerBot

10mo ago
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Rough endoplasmic reticulum

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Wiki User

12y ago
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the endoplasmic reticulum

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Anonymous

5y ago
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Q: Which organelles folds proteins?
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