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EID50 (50% endpoints infectious dose) is used to measure the amount of virus causing infection in the host, while TCID50 (50% tissue culture infectious dose) is used to measure virus infectivity in cell culture. They both represent the viral titer required to produce a specific response (infection) in a biological system, but EID50 is usually used for animal models, while TCID50 is used for experiments conducted in cell cultures.
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When you mean administrate, does this mean procedure for TCID50 or calculation for use? In calculating for the TCID50 and EID50 of the virus in question, you can either use the Spearman-Karber formula or the Reed amd Muench formula. You will be able to determine the amount of virus per 0.1 ml or 1.0 ml depending on the amount used in the procedure. There are a lot of procedure available in the net for both tests. If the computation is 105 per 0.1 ml then there are 100,000 virus particles in that volume. If you need only 103 per ml then 1.0 ml the original suspension shall be diluted with equal volume of diluent (1.0 ml.)
Is tcid50 the same as viral titer?
Tes categorically speaking yes. The titer of the virus using the TCID50 procedure shall be expressed as the titre of the virus
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