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Peripheral membrane proteins are proteins that adhere only temporarily to the biological membrane with which they are associated. These molecules attach to integral membrane proteins, or penetrate the peripheral regions of the lipid bilayer. The regulatory protein subunits of many ion channels and transmembrane receptors, for example, may be defined as peripheral membrane proteins. In contrast to integral membrane proteins, peripheral membrane proteins tend to collect in the water-soluble component, or fraction, of all the proteins extracted during a protein purification procedure. Proteins with GPI anchors are an exception to this rule and can have purification properties similar to those of integral membrane proteins.

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7y ago
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6mo ago

Peripheral proteins are loosely bound to the surface of the cell membrane, providing structural support and helping to maintain the shape of the cell. They also play roles in cell signaling, transport of molecules across the membrane, and cell-cell interactions.

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Q: What is the function of the peripheral protein?
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