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Ineffective Erythropoiesis as described by Goljan's Rapid Review in Pathology:
RBC's with alpha-chain inclusions undergo apoptosis in the bone marrow. You can see why the term is as such because RBCs are damaged/apoptosed/removed prior to release, resulting in 'ineffective' erythropoiesis.
Ineffective erythropoiesis is the active erythropoiesis with premature death of created red blood cells RBCs, a decreased output of red blood cells from the bone marrow and consequently anemia.
Ineffective erythropoiesis refers to a condition where the bone marrow produces fewer than normal functional red blood cells, leading to anemia. It can occur due to various factors such as nutritional deficiencies, chronic diseases, or genetic disorders like thalassemia. This condition can result in symptoms like fatigue, weakness, and paleness.
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What is extramedullary erythropoiesis?
Erythropoiesis is the process by which red blood cells (erythrocytes) are produced. In human adults, this usually occurs within the bone marrow. In humans with certain diseases and in some animals, erythropoeiesis also occurs outside the bone marrow, within the spleen or liver. This is termed extramedullary erythropoiesis.
What is process by which red blood cells are produced this process take place in the what?
erythropoiesis bone marrow
What would cause increased erythropoiesis?
Increased erythropoiesis can be stimulated by conditions like hypoxia (low oxygen levels), anemia, high altitude, chronic kidney disease, or certain medications like erythropoietin. These conditions trigger the release of erythropoietin, a hormone that stimulates the production of red blood cells in the bone marrow.
What is the role of b12 in erythrogenesis?
Vitamin B12 plays a crucial role in erythropoiesis by supporting the maturation of red blood cells in the bone marrow. It is involved in the synthesis of DNA, which is essential for the production of red blood cells. A deficiency in vitamin B12 can lead to impaired erythropoiesis and result in a type of anemia known as megaloblastic anemia.
What can you do to make an enzyme ineffective?
Factors such as extreme pH levels, high temperatures, or exposure to certain chemicals can denature an enzyme, altering its shape and rendering it ineffective. Additionally, changes in the enzyme's substrate-binding site can occur due to mutations or inhibitory molecules, preventing it from catalyzing reactions.
What are the causes of ineffective erythropoiesis?
thalassemia
Does erythropoiesis require folate?
Erythropoiesis requires B12, Folic acid and iron.
Do hemorrhoids cause erythropoiesis?
No
What slows down erythropoiesis?
Anemia
What does Erythropoiesis not require?
vitamin K
What are the stimuli for erythropoiesis?
There are three main events that are considered stimuli for erythropoiesis. These are aerobic exercises, living in an environment with a high altitude, and hemorrhages.
What has the author Sanford B Krantz written?
Sanford B. Krantz has written: 'Erythropoietin and the regulation of Erythropoiesis' -- subject(s): Erythropoiesis, Erythropoietin
What is the physiological state of blood that acts as the sitimulus for erythropoiesis?
Erythropoiesis (production of red blood cells) will occur when there are not enough red blood cells (RBCs) in circulation. Therefore the stimulation for erythropoiesis to occur is too few RBCs in the blood, which can be termed 'anaemia'.
What hormone acts as a stimulus for erythropoiesis?
erythropoietin
What is the scientific name for blood formation?
Erythropoiesis.
The primary site of erythropoiesis in the adult is the?
Erythropoiesis, the production of red blood cells, occurs primarily in the bone marrow of human adults.
Is talking to other employees about a situation ineffective or effective?
Ineffective
