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Angiotensin II has 4 effects: (overall effect is to increase Blood Pressure and Blood Volume)
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1. The adrenal cortex (Zona Glomerulosa)
2. Triple effect on the Nervous System
3. Supraoptic nucleus of the hypothalamus
4. Vasoconstricts smooth muscle
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1. There are Angiotensin II receptors in the Zona Glomerulosa - stimulates release of Aldosterone
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2. Direct effect on the sympathetic nervous system, increasing output. Second effect on postganglionic nerve endings inhibiting the reabsorption of Norepinephrine (i.e. increasing concentration of neurotransmitter - increasing stimulation). Third effect on reception of tissue to NE.
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3. Stimulates Supraoptic nucleus to release Anti Diuretic Hormone
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4. Direct effect on smooth muscle of a. venous system (increasing venous return, stroke volume and therefore contractility of heart muscle and cardiac output - increasing systolic blood pressure). b. arterial system (increasing resistance to blood flow, and increasing diastolic blood pressure).
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What does angiotensin-converting enzyme do?
Angiotensin-converting enzyme (ACE) is an important enzyme in the renin-angiotensin-aldosterone system (RAAS) that converts angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor that helps regulate blood pressure by narrowing blood vessels. This enzyme is also involved in the regulation of fluid and electrolyte balance in the body.
What is Angiotensin I?
Angiotensin I is a peptide hormone that is a precursor to Angiotensin II, which plays a role in regulating blood pressure and fluid balance in the body. Angiotensin I is converted to Angiotensin II by the enzyme angiotensin-converting enzyme (ACE).
What does Serum Angiotensin-Converting Enzyme do?
Serum Angiotensin-Converting Enzyme (ACE) is an enzyme involved in regulating blood pressure by converting angiotensin I to angiotensin II, a potent vasoconstrictor. It is also involved in the degradation of bradykinin, a vasodilator. Measurement of serum ACE levels can be used in diagnosing and monitoring certain diseases like sarcoidosis.
What are ACE enzymes?
ACE (angiotensin-converting enzyme) is an enzyme that plays a key role in regulating blood pressure by converting angiotensin I to angiotensin II, a potent vasoconstrictor. ACE inhibitors are a class of medications that target this enzyme to help lower blood pressure and reduce the workload on the heart.
What is one of the most potent vasoconstrictors released by the endothelium?
Angiotensin II.
Is Losartan Potassium an Ace Inhibitor?
No, Losartan Potassium is not an ACE inhibitor. It belongs to a class of medications called angiotensin II receptor blockers (ARBs), which work by blocking the effects of angiotensin II, a hormone that narrows blood vessels. ACE inhibitors, on the other hand, work by blocking the enzyme that produces angiotensin II.
What does angiotensin-converting enzyme do?
Angiotensin-converting enzyme (ACE) is an important enzyme in the renin-angiotensin-aldosterone system (RAAS) that converts angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor that helps regulate blood pressure by narrowing blood vessels. This enzyme is also involved in the regulation of fluid and electrolyte balance in the body.
Do the kidneys affect angiotensin II?
Certain kidney disorders increase the production of angiotensin II, another cause of hypertension
What triggers the release of aldosterone?
angiotensin
What is Angiotensin I?
Angiotensin I is a peptide hormone that is a precursor to Angiotensin II, which plays a role in regulating blood pressure and fluid balance in the body. Angiotensin I is converted to Angiotensin II by the enzyme angiotensin-converting enzyme (ACE).
What chemical that activates angiotensin II?
Renin
Does Renin cause a decrease in blood pressure?
No. Renin causes the blood pressure to rise. By low blood pressure the body releases Renin from the kidneys. Renin cleaves an inactive peptide, called Angiotensinogen, converting it to Angiotensin I. Angiotensin I is then converted to Angiotensin II by ACE (Angiotensin-Converting-Enzyme). Angiotensin II causes vasoconstriction and thus an increase in blood pressure.
What does Serum Angiotensin-Converting Enzyme do?
Serum Angiotensin-Converting Enzyme (ACE) is an enzyme involved in regulating blood pressure by converting angiotensin I to angiotensin II, a potent vasoconstrictor. It is also involved in the degradation of bradykinin, a vasodilator. Measurement of serum ACE levels can be used in diagnosing and monitoring certain diseases like sarcoidosis.
What are the most potent vasoconstrictors known that are peptides?
Urotensin II, Endothelin, Angiotensin II
What are ACE enzymes?
ACE (angiotensin-converting enzyme) is an enzyme that plays a key role in regulating blood pressure by converting angiotensin I to angiotensin II, a potent vasoconstrictor. ACE inhibitors are a class of medications that target this enzyme to help lower blood pressure and reduce the workload on the heart.
Production of angiotensin II indirectly?
raises the blood volume
Do angiotensin II blockers affect preload or afterload?
Afterload
