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Db-gp33-specific CD8 T cells are cytotoxic CD8 T-cells which can specifically recognize the gp33 epitope when presented in the context of the mouse MHC class I complex, H-2Db. The gp33 epitope is comprised of the sequence of amino acids in positions 33-41 of the glycoprotein from LCMV (Lymphocytic Choriomeningitis Virus).
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JordanDb-gp33-specific CD8 T cells are a specific subset of CD8 T cells that are able to recognize and target cells presenting a peptide called Db-gp33. This peptide is derived from the glycoprotein 33 of the lymphocytic choriomeningitis virus (LCMV) and is often used as a model antigen in immunology research to study T cell responses. Db-gp33-specific CD8 T cells play a crucial role in the immune response against viral infections.
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How many different types of cytotoxic t cells does the human body make?
The human body makes two main types of cytotoxic T cells: CD8+ T cells and natural killer T cells. CD8+ T cells are able to directly kill infected cells, while natural killer T cells have a broader range of targets and can also interact with other immune cells.
Which major class of lymphocytes become cytotoxic T cells?
CD8+ T lymphocytes, also known as cytotoxic T cells, become cytotoxic when they are activated by presenting antigens on major histocompatibility complex class I molecules. These cells play a key role in the immune response by directly killing infected or abnormal cells.
Which cell produces perforin?
Perforin is produced by cytotoxic T cells (CD8+ T cells) and natural killer (NK) cells. It is used in these cells to induce cell apoptosis in target cells, such as infected or cancerous cells.
What is meant CD8 or cytotoxic T cells?
A cytotoxic T-cell is a form of lymphocyte that is the "killer" T-cell. This cell engulfs damaged or viral/bacterial cells to stop them from infecting the blood.
What is the difference between T-cells and killer T-cells?
Cytotoxic T-cells are just a specialized subset of T-cells that express CD8 (a co-stimulatory molecule). In general, there are two types of T-cells, helper T-cells that express CD4 and cytotoxic T-cells that express CD8. As the name implies, cytotoxic T-cells have the role of killing any infected cells.
