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A silent mutation occurs when a change in the DNA sequence does not alter the amino acid sequence of the resulting protein. This can happen through a substitution of a nucleotide that still codes for the same amino acid due to the redundancy of the genetic code. For example, if the original sequence is "GAA" (which codes for glutamic acid) and it changes to "GAG," this would represent a silent mutation since both codons code for the same amino acid. Thus, the change in the sequence that doesn't affect the protein's amino acid sequence indicates a silent mutation.
The codon UGU codes for the amino acid Cysteine. The codon UGG codes for the amino acid Tryptophan. Therefore the mutation will cause the amino acid Cysteine to be replaced with Tryptophan. These amino acids are quite different, and the final shape of the protein could be changed as a result. This could affect the function of the protein.
A silent point mutation is a change in a DNA sequence that does not alter the amino acid sequence of the resulting protein. This often occurs due to the redundancy of the genetic code, where multiple codons can code for the same amino acid. For instance, both GAA and GAG codons code for glutamic acid, so a mutation from GAA to GAG would be a silent mutation. Thus, any codon that codes for the same amino acid as the original codon can be considered as coding for the same silent point mutation.
If a mutation resulted in the DNA sequence changing from ACG to ACT, it would alter the corresponding mRNA and potentially change the amino acid sequence during protein synthesis. ACG codes for the amino acid threonine, while ACT codes for the amino acid threonine as well. Therefore, in this specific case, the mutation might not have a significant effect on the resulting protein due to the redundancy of the genetic code, where multiple codons can code for the same amino acid. However, the impact of a mutation can vary greatly depending on the specific sequence and context within a gene.
Yes, it already has by changing the amino acid you have a mutation. That one amino acid counld be in the active site of an enzyme and that one amino acid being changed could result in loss of function or reduction in function of the enzyme. Sickle cell animea is caused by a single such amino acid substiution.
A silent mutation occurs when a change in the DNA sequence does not alter the amino acid sequence of the resulting protein. This can happen through a substitution of a nucleotide that still codes for the same amino acid due to the redundancy of the genetic code. For example, if the original sequence is "GAA" (which codes for glutamic acid) and it changes to "GAG," this would represent a silent mutation since both codons code for the same amino acid. Thus, the change in the sequence that doesn't affect the protein's amino acid sequence indicates a silent mutation.
The codon UGU codes for the amino acid Cysteine. The codon UGG codes for the amino acid Tryptophan. Therefore the mutation will cause the amino acid Cysteine to be replaced with Tryptophan. These amino acids are quite different, and the final shape of the protein could be changed as a result. This could affect the function of the protein.
A silent mutation, where a nucleotide substitution results in a codon that codes for the same amino acid, would not change the remainder of the reading frame of a gene sequence. This is because the amino acid sequence produced by the altered codon remains the same.
A silent point mutation is a change in a DNA sequence that does not alter the amino acid sequence of the resulting protein. This often occurs due to the redundancy of the genetic code, where multiple codons can code for the same amino acid. For instance, both GAA and GAG codons code for glutamic acid, so a mutation from GAA to GAG would be a silent mutation. Thus, any codon that codes for the same amino acid as the original codon can be considered as coding for the same silent point mutation.
It is neutral mutation. Codons are made up of 3 base pairs. This gives 64 different combinations, but there are only 20 amino acids, so some different codons will code for the same amino acid. When the base pair that is changed doesn't cause a change in the amino acid it codes for, then ultimately nothing happens
Amino acid order.
A mutation that causes the code for the wrong amino acid (apexvs.com)
If a mutation resulted in the DNA sequence changing from ACG to ACT, it would alter the corresponding mRNA and potentially change the amino acid sequence during protein synthesis. ACG codes for the amino acid threonine, while ACT codes for the amino acid threonine as well. Therefore, in this specific case, the mutation might not have a significant effect on the resulting protein due to the redundancy of the genetic code, where multiple codons can code for the same amino acid. However, the impact of a mutation can vary greatly depending on the specific sequence and context within a gene.
Missense
Yes, it already has by changing the amino acid you have a mutation. That one amino acid counld be in the active site of an enzyme and that one amino acid being changed could result in loss of function or reduction in function of the enzyme. Sickle cell animea is caused by a single such amino acid substiution.
The amino acid sequence is shifted, and this kind of mutation is called a frame shift mutation. All of the amino acid sequence after the mutation will be changed, which will cause a change in shape of the protein, which will then probably result in a nonfunctional protein, since the shape of a protein determines its function.
If the mutant codon still codes for the same amino acid (a silent mutation). For example: GUU, GUC, GUA and GUG all code for the amino acid Valine. So if the mutation changed the codon from GUU to GUA - Valine would still be produced and therefore the polypeptide will be identical.