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Cytokines such as interleukin-1, interleukin-6, and tumor necrosis factor-alpha are the main circulating substances that affect the hypothalamus and initiate fever by increasing the hypothalamic set point for body temperature. These cytokines are released in response to pathogens or inflammation in the body.

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10mo ago
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Q: The circulating substances that affect the hypothalamus and initiate fever are?
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