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Butalbital (5-allyl-5-isobutylbarbituric acid) is very slightly soluble in water at room temperature. It becomes moderately more soluble in boiling water. FYI, some people try to extract butalbital from Fioricet and other medications containing acetaminophen using water and filtration the same way opiates can be separated. This will not work with butalbital because it has approximately the same solubility in water as acetaminophen.
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