There are four different types of hypersensitivities. Type I Hypersensitivities are mostly Allergies and they are exaggerated, misdirected expression of immune responses to an allergen (antigen). The severity of allergies can range from atopy (local allergy such as hay fever or Asthma) or anaphylaxis (a violent and potentially fatal reaction that leads to narrowing of the bronchial airways). Foods, drugs, pollen and bee stings can trigger these reactions and this kind of sensitivity can be transferable to normal people through serum antibody.
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Inappropriate or excessive immune responses to antigens are known as hypersensitivity reactions. These can result in allergic reactions, autoimmune diseases, or immune-mediated tissue damage. Examples include allergic rhinitis, systemic lupus erythematosus, and rheumatoid Arthritis.
An immune response is based on the ability to distinguish molecules that are part of the body ("self") from those that are not ("nonself," or foreign). Such molecules that can elicit an immune response are called antigens.
Antigens incite the immune response by being processed and presented by antigen-presenting cells, such as dendritic cells, to T cells. Once presented, the antigens can activate specific immune responses, leading to the generation of memory cells and effector cells that target the antigen. Antigens that are not processed, reduced, or combined with other proteins may not effectively stimulate the immune system.
HLA1 and HLA2 are located on chromosome 6 in the human genome. They encode proteins that play a key role in the immune system by presenting antigens to T cells for immune responses.
Adaptive immune responses combat a wide range of microbes, including bacteria, viruses, fungi, and parasites. The adaptive immune system can generate specific responses tailored to each type of microbe, leading to targeted and long-lasting protection against future encounters.
Antiviral immunity targets viruses by recognizing viral antigens and activating immune responses specific to viral infections. Antibacterial immunity targets bacteria by recognizing bacterial antigens and activating immune responses specific to bacterial infections. The mechanisms of immune cell activation, the types of cells involved, and the specific responses generated differ between antiviral and antibacterial immunity.