Mechanical stimulation of a nerve physically opens ion channels in the cell membrane, allowing ions such as sodium and potassium to flow across the membrane. This creates a change in the electrical charge inside the nerve cell, leading to depolarization and generation of an action potential.
Depolarization occurs when a stimulus opens sodium channels which allow more sodium to go into the membrane making it less negative and more positive (toward reaching threshold). An action potential can only occur once the membrane reaches threshold which means it has reached the level needed through depolarization. An action potential is a brief reversal in polarity of the membrane making the inside more positive and the outside more negative, the reverse occurs again once the membrane reaches resting potential.
Action potentials propagate from an influx of Na and an efflux of K along an excitable cell (neuronal or muscular). If you think of a zipper with two heads attached to the top, as one zipper head traverses down and opens the zipper the next zipper goes down to close. The first zipper head is the action potential going down an axon. It is able to proceed because there is a membrane potential difference between outside the cell and inside the cell. A normal neuron has a membrane potential of -70mV. That means inside the cell is more negative than outside the cell. So when an action potential is elicited, Na rushes in and K rushes out. This produces slight changes in the membrane potential causing it to go up to around +35mV (inside cell). As this happens right next to that Na and K channels are more Na and K channels that see this happening and they open up in response. This occurs like the first zipper head going down. The second zipper going down is the efflux of Na and influx of K to restore the membrane potential back to normal. When the action potential reaches the end, called terminal bouton, calcium channels that are there waiting for this action potential open up and allow a rush of calcium into the terminal bouton. The calcium serves a separate function to push out little vesicles called neurotransmitters out of the cell to continue an action potential into a different cell.
1. Resting potential: all voltage-gates are closed. 2. At threshold, Sodium activation gate opens and Sodium permeability rises. 3. Sodium enters the cell (influx), causing an explosive depolarization to +30 mV, which generation the rising phase of action potential. 4. At peak of action potential, sodium activation gate closes and sodium permeability falls, which reduces the net movement of sodium into the cell. At the same time potassium activation gate opens and potassium permeability rises. . 5. Potassium leaves the cell (efflux), causing the repolarization to resting potential, which generates the falling phase of action potential. 6. On return to resting potential, sodium activation gates closes and inactivation gates opens, resetting channel for another depolarizing triggering event. 7. Further outward movement of potassium through still open potassium channels briefly hyperpolarize membrane, 8. Potassium activation gate closes and membrane returns to resting potential
Yes, a neuron becomes more negative during a nerve impulse due to the temporary increase in membrane potential known as hyperpolarization. This is caused by the efflux of potassium ions during repolarization after an action potential.
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depolarized, which triggers an action potential and leads to muscle contraction.
Mechanical stimulation of a nerve physically opens ion channels in the cell membrane, allowing ions such as sodium and potassium to flow across the membrane. This creates a change in the electrical charge inside the nerve cell, leading to depolarization and generation of an action potential.
In general, action potentials that reach the synaptic knobs cause a neurotransmitter to be released into the synaptic cleft. The arrival of the action potential opens voltage-sensitive calcium channels in the presynaptic membrane.
Bolt
Depolarization occurs when a stimulus opens sodium channels which allow more sodium to go into the membrane making it less negative and more positive (toward reaching threshold). An action potential can only occur once the membrane reaches threshold which means it has reached the level needed through depolarization. An action potential is a brief reversal in polarity of the membrane making the inside more positive and the outside more negative, the reverse occurs again once the membrane reaches resting potential.
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The nervous stimulus passes to the motor end plate through the release of acetylcholine from the axon terminals. This neurotransmitter binds to receptors on the motor end plate, causing depolarization of the muscle cell membrane and initiating muscle contraction.