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Thalidomide caused severe birth defects in babies whose mothers took the drug during pregnancy. These birth defects included limb deformities, such as missing or malformed limbs, as well as other malformations of organs like the ears, heart, and digestive system. Thalidomide exposure during pregnancy led to a tragic and widespread public health crisis in the 1950s and 1960s.
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How do you know if someone had Thalidomide overdose before his death?
An autopsy can reveal signs of Thalidomide overdose, such as the presence of the drug in the person's system or physical symptoms of toxicity. Blood and tissue samples can be tested for Thalidomide levels to confirm an overdose. Additionally, the person's medical history and any prescriptions they were taking can provide clues to potential overdoses.
How could thalidomide disaster been prevented?
The thalidomide disaster could have been prevented by conducting more thorough preclinical and clinical testing to assess its safety and efficacy, particularly its potential to cause birth defects. Stronger regulations and oversight from governing bodies could have also helped prevent the tragedy by ensuring stricter approval processes for new medications. Additionally, greater transparency in reporting and communicating potential risks associated with thalidomide use could have helped raise awareness and prevent widespread harm.
Are twin heartbeats different?
Yes, twin heartbeats can be different due to variations in position, development, and size of the babies. Factors such as gestational age, health of the babies, and umbilical cord connections can also affect the variation in twin heartbeats. It is important for healthcare providers to monitor both babies closely to ensure they are developing well.
Does age affect exposure to chemicals?
Age does affect the exposure to chemicals. Babies and children generally have a higher risk of negative effects due to the exposure of harmful chemicals. An unborn fetus is the most susceptible. This is due to the fact that their organs are not fully developed.
What is the influence of Rh factor on babies?
Rh factor is a protein found on the surface of red blood cells. If a woman who is Rh-negative is carrying an Rh-positive baby, her body may develop antibodies against the Rh factor, which can lead to complications in future pregnancies. This can cause hemolytic disease of the newborn (HDN), where the mother's antibodies attack the baby's red blood cells, potentially resulting in anemia or jaundice in the baby.
Why was thalidomide prescribed to a pregnant women?
Doctors often prescribed Thalidomide to pregnant women to treat morning sickness and as a sedative to assist with sleep. Thalidomide was sold from 1957 until 1961. The product was withdrawn when it was discovered that Thalidomide was teratogenic - causing malformations of an embryo or foetus. Countless babies were born with birth-defects; most notably missing limbs.
Why was the testing inappropriate for thalidomide?
It Caused Unexpected Damage To The Babies Of Thousands Of Pregnant Women.
What is the chemical formula of thalidomide?
The chemical formula of thalidomide is C13H10N2O4.
How did Thalidomide help pregnant women?
Thalidomide was supposed to be an effective sedative for pregnant women, but thalidomide caused birth defects and peripheral neuropathy.
How did thalidomide cause birth deformities?
This occurred due to the fact that the first manufacturer of thalidomide was a German pharmaceutical company - which first sold this drug in October of 1957. This was followed by British approval of the drug. Subsequently, over the next ten years or so, about 2,500 "thalidomide babies" were born in Germany, and about 2,000 in Great Britain. The birth defect is called phocomelia, a shortening of the limbs, in which they appear to look like the flippers on a seal. Also, the FDA did not approve thalidomide in the U.S. (although quite a few tablets found their way to the U.S., despite the FDA ban).
What are some books about the thalidomide disaster?
Dark Remedy: The Impact of Thalidomide and Its Revival as a Vital Medicine by Rock Brynner and Trent D. Stephens Suffer the Children: The Story of Thalidomide Tough Cookie: The Less Than Virtuous Tale of a Thalidomide Mum by Sheila Mottley Thalidomide and the Power of the Drug Companies (A Penguin special) by Robert Nilsson and Henning Sjostrom Dark Remedy: The Impact of Thalidomide and Its Revival as a Vital Medicineby Rock Brynner and Trent D. Stephens Suffer the Children: The Story of Thalidomide Tough Cookie: The Less Than Virtuous Tale of a Thalidomide Mum by Sheila Mottley Thalidomide and the Power of the Drug Companies (A Penguin special) by Robert Nilsson and Henning Sjostrom
What was Thalidomide originally intended to cure?
Thalidomide was orginally created to help cure morning sickness (a common side effect of pregnancy) and it worked out great! but the side effect was that it made gross defects on the babies born(missing/distorted limbs, etc.) so it was take off the shelves in 1962 and is not used for this purpose anymore.
How does the drug thalidomide work?
Thalidomide regulates the immune response by suppressing a protein, tumor necrosis factor alpha.
When in pregnancy did thalidomide affect baby?
The thalidomide sensitive period goes from day 21 past conception onwards to day 42. (Dr Janet McCredie, "Thalidomide - Birth Defects Explained", London, The Royal Society of Medicine Press, 2007, p. 189 and many other places in the book} McCredie suggests, p. 126, that the hypothesis of neural crest injury is the underlying pathogenetic mechanism of many congenital malformations. And concludes, pp. 150 - 151, that the thalidomide-sensitive period coincides with neural crest development, but not with limb development That's what I understand. I have no knowledge of (human) biology and related sciences. I'm only a dumb thalidomide-monster.
Who invented thalidomide?
Thalidomide was developed by the German pharmaceutical company Chemie Grünenthal in the 1950s. It was marketed as a sedative and antiemetic medication before its teratogenic effects became apparent.
What actors and actresses appeared in Happy Birthday Thalidomide - 2004?
The cast of Happy Birthday Thalidomide - 2004 includes: Mat Fraser
How did the living conditions in buildings in the slums affect babies?
they made babies sick
