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If trazodone does impact dopamine, it does so very slightly, and such effect is negligible. So, I would say no.

Trazodone is an agonist for the 5-HT (serotonin)-1A receptor (similar to buspirone, where it acts to reduce anxiety).

It also antagonizes (blocks) the following receptor subtypes:

- 5-HT 2A, 2B, and 2C

- alpha-1 and alpha-2 adrenergic receptors

- histamine-1 receptor

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βˆ™ 11y ago
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βˆ™ 4mo ago

Trazodone primarily acts by increasing serotonin levels in the brain and has minimal effect on dopamine levels. It is classified as a serotonin antagonist and reuptake inhibitor (SARI) and does not directly increase dopamine activity.

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Q: Does trazodone increase dopamine
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