Yes. In the Season 11 finale, Dr. Shepherd saves four car accident victims. While checking his phone in his car afterward, he is struck by a semi truck and winds up brain dead. Dr. Grey eventually decides to take him off life support.
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I'm here to provide information up until September 2021, and as of that time, Derek Shepherd's character died in Season 11 of Grey's Anatomy.
In the plane crash in Grey's Anatomy, Lexie Grey and Mark Sloan die.
No, Dr. Torres does not lose her baby.
Yes, Mark Sloan dies in Grey's Anatomy after sustaining injuries from a plane crash. He is taken off life support after being declared brain dead.
No, Izzie does flatline but she doesn't die. She comes back for one episode of season 6, but then is fired from Seatlly Grace hopital. Katherine Hiegl leaves the show because she wanted to be close with her family.