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Yes this will show up on a drug test, it is an opiate, which is tested on all drug tests. Just like hydrocodone is an opiate. Addictions Graduate

No it won't, it's a trycicylic antidepressant and not an opiate, that targets muscle pain and spasms.

IMPROVEMENT TO ANSWER: The second poster is absolutely correct in saying that Cyclobenzaprine (Flexeril, Amrix, Fexmid) is structurally indeed a tri-cyclic antidepressant. It IS ABSOLUTELY NOT an opiate. It is a medication that is utilized for it's muscle relaxation effect to facilitate muscle healing after strains. It is also used for other medical conditions. The exact mechanism of action remains a subject of great debate in professional circles, but it is mostly believed to activate the locus coeruleus in our brain stem. The locus coeruleus, also known as the "LC", is located in the dorsal wall of the Rostral Pons on the lateral floor of the 4th ventricle of the brain. LC stimulation causes our brain to release large amounts of norepinephrine into the spinal cord and thus nerves which gives this musculo-skeletal pain relief and relaxation. Opiates are completely different, as they affect the brain's cerebral opioid receptors.

In summary, Cyclobenzaprine does not show up on the basic drugs of abuse panel which is used for most drug testing at workplaces, schools, probation and parole and other "legal" testing purposes. There is what is called a comprehensive toxicology screen that can detect over 220 medications, and THIS test can show Cyclobenzaprine in the system. If you have a comprehensive test it is usually for medically diagnostic purposes to heal and cure medical patients by testing for organ toxicity and other reasons. Bottom line, if you are taking a prescription medication without a prescription, then you are technically violating many occupational and legal regulations and could be terminated from your job, or have your probation/parole revoked. A prescription medication is a CONTROLLED SUBSTANCE. If you are in possession of such a medication without a prescription, you are in violation of federal law.

Hope this helps. Might I suggest the Addictions Graduate see his or her addiction professional for guidance and remedial education.

Joseph Abbott, M.D.

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15y ago

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