I can't find this in an episode of American Dad.
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GAGA is a reference to super theatrical band, Queen's, song Radio Gaga.
I have only found one reference of here being hogtied but it said that it was for publicity.
Bessie Coleman and Zendaya Coleman are not related at all. Bessie Coleman was a pioneering African American aviator in the early 20th century, while Zendaya Coleman is a contemporary actress and singer known for her roles in Disney Channel shows and movies. They may share the same last name, but that's where the connection ends.
No i dont think so. I searched it and it came up with no results of them being related. Also i think Ruben is creepy.
No. I cannot find any report of Carl and Musiq being related.