The actress who played Dr. Mel Karnofsky on Frasier is Jane Adams. She makes her debut appearance in the episode titled 'The Late Dr. Crane'.
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From the TV show Frasier? His brother is Niles Crane.
Niles' wife is called Maris. but later in the series He marries Dr. Mel Karnoski, and finally Daphne Moon
Christine Baranski.
The television show, "Frasier" produced new episodes from 1993 to 2004. Frasier filmed over 264 episodes! Kelsey Grammer played the main character Dr. Frasier Crane.
Yes, she played Dr Honey Snow in two episodes.