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Human skin makes an excellent seal against the vacuum of space. Beyond that there are a lot of things to take into consideration. But if only the hand is exposed, then it will swell slightly as the internal body pressure press out. As heat loss on earth is due to conduction, convection and radiation In a vacuum there is no water or air molecules, so heat loss is through radiation Unless you touch a cold object then conduction heat loss would occur. Direct exposure sunlight would warm it up quite a bit. NASA has compiled quite list based on industrial accidents on the extents of a vacuum environment on the human body.

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