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When Elizabeth Weir was seriously wounded by the Asuras (a form of replicators invented by the Ancients to combat the Wraith), Rodney McKay injected her with deactivated nanites which will repair her damage, although in the end she will be no longer fully human, but part replicator. She sacrificed herself when Sheppard's team was on a mission to steal Zero Point Modules from the Asuras. A replicator version of Jennifer Keller told the team that later after they abandoned Elizabeth, she was killed by Oberoth. But apparently, this was not the case.

Elizabeth Weir teamed up with a couple of replicators that wanted to find a way to ascend like the ancients. She and the other replicators did ascend, but only 'digitally'. In the episode: Ghost in the Machine, Elizabeth Weir came back to Atlantis and took control of Atlantis's computer systems and made bodies for her and the other replicators, using Rodney's FRAN templates. Later in the episode, a replicator named Koracean tries to escape, finally understanding that she and the other replicators are only danger to Atlantis, Elizabeth managed to fool the other replicators (with the help of the team) into a Stargate to a space gate, making the replicators including herself neutralized.

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Q: What happened to Dr Weir in Stargate Atlantis?
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