In the last episode of Season 10, Lex Luthor lost his memory as a result of Tess Mercer touching him with neurotoxin which was poison that resulted in Lex losing all of his memories prior to Tess putting the neurotoxin on his left cheek.
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Dr. Helen Bryce was the one who was responsible for the attempted death of Lex Luthor in Season 3 of Smallville.
Yes, Lex Luthor returned in the last episode of Smallville which is titled "Finale."
It's episode 19, season 6. Have fun!
Season 7 was the last season for Michael Rosenbaum and John Glover who respectively portray Lex Luthor and Lionel Luthor.
Smallville has six more episdoes to go before the show finishes for season seven. Want to find out more go to the smallville site at www.kryptonsite.com. To get the lastet and greatest about Smallville and it's actors.