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No. Americans have died on the way up or the way back (both Space Shuttle missions) and some died in training (Mercury) also some Soviets have died on re-entry but none have died "in-space." The most dangerous parts of space flight are like airplane flights- take off and landing.
A number of astronauts have died after returning from space. However, I believe you're asking if they have died AS A RESULT OF being IN space--and the answer to that (with the possible exception of the Columbia tragedy) is no.
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