Sign the word WRONG while having a concerned look on your face. Make a fist and turn the fingers toward your ... back of your hand to the person. Stick out your pinky and thumb (Google-image the Hawaiian "Hang Loose" sign ... it is the same). Put the knuckles of your fist/sign to your chin and pull it down. Dont' forget to show concern in your face.
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In American Sign Language, you can sign "what's wrong" by signing "what" with a furrowed brow and signing "wrong" by pointing to the side with your thumb up and twisting your hand slightly.
No, it is more appropriate to say "communicate in sign language" as sign language is a visual-gestural language and not spoken.
In American Sign Language, you can sign "WHEN YOU BORN?" to ask someone when they were born.
To sign "Are you happy?" in American Sign Language, you would sign: YOU HAPPY? with raised eyebrows.
In American Sign Language (ASL), you can sign "I can understand" by signing I-KNOW, UNDERSTAND.
In American Sign Language (ASL), you can sign "I know" by pointing to your head with your index finger.