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The main problem with enzymes is that they are very sensitive to their surroundings. For enzymes to function properly the temperature must be kept down (usually below 45oC). The pH also needs to be kept within carefully monitored limits which suit the enzyme. It costs money to control these conditions.ØEnzymes are very sensitive to their surroundings. For enzymes to function properly the temperature must be kept down (usually below 45oC). The pH also needs to be kept within carefully monitored limits which suit the enzyme. It costs money to control these conditions.

ØSmall changes in these conditions will make them denatured

ØEnzymes require a lot of energy

ØPeople can develop Allergies to enzymes such as biological washing powder

ØThey are expensive to produce

ØContamination of the enzyme with other substances can affect the rate of reaction.

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