For starters: USAF CPT H. Alston, 435th Tactical Fighter Squadron (TFS), was the first (successful/without getting shot down) F-104 Starfighter pilot to fly 100 missions over North Vietnam in September 1966. Aircraft wise: The USAF F-100 Super Sabre flew over 360,000 combat missions during the Vietnam War.
If they were on official missions yes.
Actor James Stewart (Jimming Stewart) a B24 Liberator squadron commander in WWII, and a retired USAF (Reserve) General who flew some B52 Bomber missions over North Vietnam, lost a son in Vietnam, a USMC Lieutenant. Unknown about his nationality background.
C130
The name was the Tuskegee Airmen.
According to available information, there were around 2,225 search and rescue missions conducted by the U.S. military during the Vietnam War. These missions were aimed at locating and rescuing downed aircrews or individuals in distress.
Many flew more missions than that.
If they were on official missions yes.
Yes, many USAF Reserve squadrons flew combat missions in Vietnam; especially from the F100 Supersabre units.
John McCain was a fighter pilot in the US Navy and flew combat missions in Vietnam.
5 operational Space Shuttles were built, Columbia, Challenger, Discovery, Atlantis and Endeavour. Challenger was destroyed in an explosion during launch and Discovery was destroyed when it disintegrated during re-entry. Neither accident was caused by the orbiter itself. They all flew mission of national or scientific interest. Columbia flew 28 missions. Challenger flew 10 missions. Discovery flew 39 missions. Atlantis flew 33 missions. Endeavour flew 25 missions.
B52s normally flew over North Vietnam on bombing missions in groups of 3 bombers. These were called "cells." Or 3 plane cells. A formation might consist of up to 20 cells or 60 bombers.
The USAF & USN bombed N. Vietnam. The USMC flew combat missions in support of Marines in SOUTH Vietnam. US Warships stationed off the coast of NORTH Vietnam were operating in "Yankee Station." US Warships stationed off the coast of SOUTH Vietnam were designated "Dixie Station."
7 astronaut did
Actor James Stewart (Jimming Stewart) a B24 Liberator squadron commander in WWII, and a retired USAF (Reserve) General who flew some B52 Bomber missions over North Vietnam, lost a son in Vietnam, a USMC Lieutenant. Unknown about his nationality background.
Kamikaze pilots
The Apollo program consisted of a total of 17 missions, with 10 crewed missions (Apollo 7-17) and 7 unmanned missions.
I would have to say it was the United States Army Air Force and the United States Naval air force that flew the most missions. Here is my reasoning. The US was not only flying missions in Europe they were also flying missions in the Pacific theater. So they would add all up all those missions and I can be fairly certain they out numbered the Royal Army Air Force mission total. Now which particular group flew the most? I heard it was the 9th Air Force and one of the RAF groups but some of the 9th Air Force was sent to the Pacific so I still think they would win the title of flying the most missions.