Sean Taylor was a famous NFL player who wore Number 21 for the Washington Redskins. He was murdered when he was shot during a botched robbery/home invasion.
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All NFL teams wore #21 on their helmets in Week 13 of 2007, to honor Sean Taylor, the Redskins star who was killed. Some, but not all, NFL teams continued wearing the number for the rest of the season.
Roberto Clemente wore uniform number 13, and 21 during his first year in 1955 with the Pittsburgh Pirates, and wore uniform number 21 the rest of his career from 1956 -1972.
Paul Blair wore number 2 from 1977-1979 and number 27 in 1980, when playing for the New York Yankees.
Charles Woodson Willie wood
Rickey Jackson wore #57 for the New Orleans Saints from 1981-1993.