Among the reasons Jamestown, Virginia was eventually abandoned include the rampant diseases that pervaded the colony. Its situation on a swamp proved to be a perfect breeding ground for malaria-carrying insects that wreaked havoc on the settlers.
In addition, being one of the early Europeans that the natives encountered for the first time, the colonists suffered through multiple Native American raids. Supplies from the mother country also found it difficult to navigate the turbulent waters near where Jamestown was settled, which caused the eventual starvation of a large percentage of the original settlers.
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the settlers lacked some of the necessary skills needed to provide for themselves
The main problems that the early settlers of America faced were: Disease: Malaria, Smallpox, Cholera. Indian tribe attacks: King Phillips War, Roanoke Island, Jamestown Massacre or(Indian Massacre of 1622) Crop Failure: In Jamestown, the settlers arrived to late in the year to plant crops. Many early settlers of the Virginia Colony were unaccustomed to hard labor and the settlement was not producing enough to sustain themselves.
Jamestown was built by some 500 commercially inspired settlers from England sponsored by the Virgina Company of London.
Jamestown was founded first, and was a financial venture (they hoped to make money) Plymouth was settled for religious reasons. First settlers at Jamestown were all men, some of the first settlers at Plymouth were women.
Some of their food came from their harvest, but only 1%. The other 95% came from the Indian Cheif Powhatan.