There was a big Senate fight on the route it would take. Stephen Douglas and Henry Clay were at odds about the route. Douglas wanted it to go through Chicago and have that as the main hub. Clay wanted it in St. Louis. Both men spent a great deal of time using their power in the Senate over the route. Douglas won and it went to Chicago ( where it still is today). This resulted in Douglas gaining more power in the Senate and becoming more nationally known. It gave him the platform to run for President against Lincoln. Most of his power was invested in southern states and with the south, so had he won the office there may have not been a civil war, but the issue of slavery would not have been settle in the 1860's. At some point it was bound to have a resolution, but it would have been later and bloodier.
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Ulysses Grant was the US president when the transcontinental railroad was finished in 1869.
If this question refers to the US's transcontinental railroad, then the answer is Promontory Point, Utah. There in the Spring of 1869, the Union Pacific and Central Pacific railroads met, creating the US's transcontinental railroad.
The Transcontinental railroad was completed in a ceremony in the Utah Territory in 1869. The railway enabled travel from the US east coast to the west coast.
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Gadsen Purchase