They would be cousins to some degree.
They are 2nd cousins.
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Relationship sequence:Your uncle is your mother's brotherHis children are your first cousinsHis grandchildren are your first cousins once removed
There is no word in the English language for a relationship between grandmothers of related grandchildren
1st cousin 2x removed
Your ancestors are the people whose children lead eventually to you. They are your mother and father, grandmothers and grandfathers, great grandparents, great great grandparents, etc. Your cousins are the children, grandchildren, great grandchildren, etc, of the brothers and sisters of your ancestors.
Your son and your sisters child are first cousins. The granddaughter is out of synch by a generation. That will make them first cousins once removed.