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Leads are not generally kept in the records, so finding the biggest lead is difficult. The biggest blowout, however (which also means the biggest lead to end a game with), is 68, when the Cleveland Cavaliers beat the Miami Heat by a score of 148-80.
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Who played in the biggest blowout in nba history?
68 - The Cleveland Cavaliers defeated the Miami Heat 148-80 on December 17, 1991.
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